Management and finance
Peter de Keizer, PhDManaging Director
Peter de Keizer, PhD
Managing director
Peter de Keizer is the founder and managing director of Cleara Biotech B.V. He has 10+ years experience in valorization, intellectual property and preclinical research and development. He is and associate professor “Senescence in Cancer and Aging” at the University Medical Center Utrecht, the Netherlands. Peter was trained as a molecular biologist at Utrecht University and Harvard Medical School / Mass General Hospital, Boston, MA, USA (2004). He performed is PhD in 2009 in the field of FOXO signaling, knowledge he employed during his postdoctoral work at the Buck Institute for Research on Aging in Novato, CA, USA (2012) to develop the first compounds to eliminate senescent cells: FOXO4-based peptides. In 2017, he showed the translational power eliminating at least some types of senescent cells in mice, which resulted in a restoration of tissue homeostasis in models for aging and chemotoxicity (Cell, 2017; cited >700 times). In 2018, he joined the UMC Utrecht, the Netherlands, to investigate subtypes of senescence, where he became associate professor in 2020. Peter has been awarded several awards for his work on targeting senescence, including “talent extraordinary”(2013), ambassadorship of the Dutch Cancer Society (2017). He is a recurring guest in mainstream media on topics of aging and/or senescence and is regularly approached by policy markers for advice. He is an active member of the European Association for Cancer Research and the International Cell Senescence Association. Through Cleara Biotech B.V. he is dedicated to merge academic knowledge on senescence subtypes to develop new compounds and bring these to the clinic against late state cancer and chronic diseases.
François R. Martelet, MD, MBABusiness Advisor
Francois Martelet
Business Advisor
Seasoned senior executive with over three decades of international leadership in the pharmaceutical and biotechnology industry, combining a rare trifecta of medical, business, and legal credentials. Notably served as Vice-President & Global Franchise Head, Oncology at Merck & Co., Inc. (Whitehouse Station, NJ), where he held worldwide strategic and commercial accountability for the oncology portfolio. Prior to and following that role, has served as Chief Executive Officer of multiple publicly listed oncology and specialty pharma companies across Europe and the United States, including Scandion Oncology (Copenhagen), Vivesto AB (Stockholm/NASDAQ), TopoTarget (Copenhagen/New Jersey), and AVAX Technologies (Philadelphia/Lyon). Earlier in his career, held Senior Vice-President and Vice-President positions at Novartis Pharma, with regional leadership across the US, Europe, and InterContinental markets, and progressive roles at Roche and Eli Lilly. Academic foundation includes a Doctorate in Medicine with distinction, a Master’s degree in Pharmaceutical Marketing (Burgundy Business School), and advanced training at INSEAD and Harvard Business School. Brings deep expertise in oncology drug development, business turnarounds, early-stage biotech commercialization, investor relations, and cross-border strategic partnerships.
Nick Sarlis, MD, PhDChief Medical Officer
Nick Sarlis, MD, PhD
Chief Medical Officer
Dr. Sarlis has (co-)managed the medical strategy prior and during the launch of 6 globally marketed products, helped progress 20 pipeline agents along their clinical development path, and has participated as a site investigator in 38 studies and 2 registries. He is an experienced clinician, senior medical researcher and recognized pharmaceutical and biotech industry leader. Until recently, Dr. Sarlis led the Medical Content function within Amplity Health. Prior to that, and in reverse succession, Dr. Sarlis served as CMO of The Lynx Group, a senior consultant for IPQ Analytics, as well as CMO of Sellas Life Sciences Group, Inc., where he led the clinical development of two peptide-based cancer vaccines. Before that, Dr. Sarlis served as Head of Medical Affairs at Incyte Corp. and held positions of increasing seniority at Sanofi, both in the US and France. Prior to his industry positions, he was a faculty member at the MD Anderson Cancer Center and the US National Institutes of Health. Dr. Sarlis obtained his Doctor of Medicine and DrMedSci degrees from the University of Athens, Greece, and a PhD from Imperial College, University of London. Dr. Sarlis is certified by the American Board of Internal Medicine and the National Board of Physicians and Surgeons (US), and is an elected Fellow of the American College of Physicians. Dr. Sarlis has published 135 articles and textbook chapters.
Frank Niemöller,Head of Finance
Frank Niemöller
Head of Finance
Frank Niemöller has over 30 years experience in finance and operations management in the biotech, medtech, foodtech, health insurance and telecom industries.
Next to Cleara Biotech he is also working at Mosa Meat as Head of Finance, a food tech company leading in the cultivated meat space and he is financial advisor for several start-and scale ups. As part of his prior experience he was for 15 years CFO at Optelec Holding BV, an international market leader in the development and supply of electronic aids for the visually impaired and for over 4 years CFO at Facio Therapies, a Netherlands-based company with a single focus – to overcome FSHD
by developing a causal therapy that restores the natural repression of muscle-toxic DUX4. As part of his prior experience, he was corporate controller at Pharming Group NV, the specialty pharmaceutical company developing innovative products for treatment of rare diseases and unmet medical needs.
Frank received a Masters degree in Business Economics at Erasmus University Rotterdam
Marjolein Baar, PhDHead of Research
Marjolein Baar, PhD
Marjolein Baar is a senior scientist at Cleara Biotech with 10+ years of experience in cellular senescence in cancer and aging. Her main interest is to study cellular processes that underlie organismal aging and she aims to provide starting points for the development of potential treatments. At Cleara she focuses on translation of Cleara’s lead compounds, employing both cell and in vivo models. She plans projects and oversees experiments regarding compound screening, efficacy in multiple model systems, and pharmacokinetics. Before joining Cleara, Marjolein obtained her Ph.D. degree at the Erasmus University medical center in Rotterdam. Here, she drove multiple projects all aimed to unravel the mechanisms and functions of age-related DNA damage responses. A major part of this research focused on characterizing senescent cells and their effect on tissue homeostasis during aging and cancer. Her work resulted in a publication in Cell and aided in the foundation of Cleara.
Preclinical and Clinical
Dr. Jörg Herbst Dipl. Chem. PhD, ERT, DABTProjectmanager preclinical research
Dr. Jörg Herbst Dipl. Chem. PhD, ERT, DABT
Jörg is a Board-Certified Toxicologist in the EU (ERT) and the US (DABT) with over 20 years of experience in the Biopharmaceutical Industry. Jörg holds a degree in Chemistry and received his PhD from the Institute of Toxicology at the University of Würzburg.
Jörg worked for a range of biotech companies as an expert in the field of non-clinical development and safety evaluation and thereby collected a proven track record of moving discovery projects of various molecular scaffolds (polypeptides, fusion proteins, monoclonal antibodies, DARPins, cancer vaccines) into clinical development and towards market authorization.
Jörg has considerable experience in planning and execution of non-clinical safety and efficacy assessments and elaboration of program budgets and timing of such nonclinical packages in support of clinical programs in a broad range of indications and throughout all development stages. He profits from his profound knowledge on GLP requirements, regulatory guidelines on nonclinical development and his excellent contacts to numerous CROs. He has supervised a multitude of pivotal GLP toxicity and safety pharmacology studies and has authored several Investigator’s Brochures and other
Michael Teifel, PhDPreclinical development
Michael Teifel, PhD
Head of preclinical development
Dr. Teifel is a leading industry executive with a career spanning over 20 years in various therapeutic areas, including endocrinology and oncology. He has deep experience in translating research into clinical development. Over the course of his career, he has gained particular expertise in the design and implementation of non-clinical development programs for small molecule drugs, peptides, targeted therapies, and biologics, as well as in the continued non-clinical evaluation of drug candidates for global registration.
Dr. Teifel held various positions in industry with increasing responsibilities in pharmacology, pharmacokinetics, toxicology and translational sciences. He began his career in industry at Roche Diagnostics in the area of delivery systems / non-viral gene therapy. In 1999, Dr. Teifel joined the biotech start-up, Munich Biotech in Martinsried, Germany as a co-founder. As head of pharmacology & toxicology, he was responsible for the evaluation and non-clinical development of a novel vascular targeting technology for the development of anti-tumor diagnostics and therapeutics. In 2004, Dr. Teifel started his first term at Aeterna Zentaris where he held several positions in the field of preclinical development and translational research. In his capacity he was, among others, responsible for preparation of the non-clinical dossier for registration of macimorelin in the U.S. and EU in the indication AGHD. In 2019, Dr. Teifel left Aeterna Zentaris to pursue his career in non-clinical research and development at Cleara Biotech in Utrecht, The Netherlands. As head of translational sciences at Cleara Biotech, he was responsible for translating research on anti-senescent drugs into pre-clinical development in age-related diseases and late-stage cancer and returned to Aeterna Zentaris in 2021 and has been a consultant to Cleara since then.
Tobias Madl, PhD (Prof.)Head of structural biology, scientific co-founder
Tobias Madl, PhD (Prof.)
Tobias Madl is Full Professor for Integrative Structural Biology and Metabolomics at Medical University of Graz and has more than 15 years experience in structural biology and more than 140 publications in this field, including high-ranking journals. He works at the interface between structural biology, biophysics, cell biology and medicine. NMR spectroscopy and biophysical methods are the most important tools in his laboratory. In Graz, Tobias is Head of the inter-University Integrative Metabolism Research Center and Speaker of the International PhD program Biomolecular Structures and Interaction (BioMolStruct). Prior to joining Medical University of Graz in 2015, he was Research Group Leader at Technical University and Helmholtz Center Munich, Germany, and PostDoc at Utrecht University, The Netherlands, and Technical University Munich. Tobias obtained his PhD degree with distinction in Chemistry from the University of Graz, and conducted his PostDoc research focusing on Integrative Structural Biology of RNA-binding proteins at Technical University Munich. His research has been honored with several awards and fellowships. Tobias research passion is to reveal the mechanisms of how disordered proteins mediate signal transfer via an intricate network of protein interactions and post-translational modifications and to discover and develop novel strategies to target these interactions in ageing and age-related diseases.
Laurens van PinxterenHead of Technical Operations
Laurens van Pinxteren
Project control and Finance
Laurens van Pinxteren, PhD, MBA has more than 20 years of experience as CMC/program management in the biotech industry including small entrepreneurial start-ups. He has strong experience in chemistry, manufacturing and controls (CMC) in relation to scale up, tech transfer (process/methods), CDMO oversight, clinical supply chain, and quality regulatory affairs.
Laurens started his career, following an academic period and his MBA, as a consultant at the pharma/biotech consultancy firm Xendo (now ProPharma Group) followed by a program management position at CDMO OctoPlus. In 2010, he joined ProFibrix as Director Manufacturing & Supply and continued after the 2013 acquisition by The Medicines Company up to early 2016. At Profibrix, he was instrumental in obtaining MAA/BLA approvals for Raplixa in 2015. In early 2016, he moved to InteRNA Technologies as VP CMC & Regulatory Affairs and later became the COO. In 2014, he also started his own consultancy company (CMC Biotech Consultancy) and has since supported several (small) biotech companies in their CMC/RA activities for a wide range of drug substances and products.
Laurens received a Masters degree from the Wageningen University, NL, a PhD in Veterinary Medicine from the University of Edinburgh, UK, and a MBA from the Rotterdam School of Management at Erasmus University, NL.’
Back office
Edo BrinksmaProject control and finance
Edo Brinksma
Project control and Finance
Edo Brinksma has over 20 years of experience in finance and (project) control. Edo started his career at the Big-4 audit firm Deloitte. Edo has been working as a freelance (finance) consultant since the beginning of 2007. As a freelance consultant Edo was engaged in (senior) financial positions of public and private entitiessuch as UMC Utrecht, Princess Maxima Center, the municipality of Zwolle, Rijksdienst voor het Cultureel Erfgoed (RCE, Cultural Heritage Agency of the Netherlands) etc
Clementine NichollsExecutive Assistant
Clementine Nicholls
Clementine Nicholls-Dohmen is the Cleara Biotech Executive Assistant with a very broad experience in many areas. Clementine studied at the Higher Institute for Interpreters and Translators in Brussels, Belgium and is consequently perfectly bilingual (Dutch, English) and can express herself in Spanish, French and German.
Furthermore Clementine gathered a lot of experience by assisting executive and sales officers in different international companies such as, Koninklijke Nederlandse Papierfabrieken, Conticommodity Services, Protein Technologies, Watt Global Media and Ariëns Schoonderbeek Advocaten, as well as management of the family firm as an independent entrepreneur. This makes Clementine a very efficient multitasker, well organized, able to meet deadlines and work well under pressure, show leadership in getting the job done and working successfully as a team player.